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upa selective inhibitor uk122  (Santa Cruz Biotechnology)


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    Santa Cruz Biotechnology upa selective inhibitor uk122
    Effect of uPA inhibitor on DSS-induced colitis in C57BL/6 J mice. ( A ) Male mice were administered 2% DSS in their drinking water for 1 week, and intraperitoneally injected with 2 mg/kg or 4 mg/kg <t>UK122</t> or vehicle from day 1 to day 7 (n = 18 per group). They were sacrificed at day 8. ( B ) Representative macroscopic images of the colon in each group. The lower right panel represents a colorectum of mice that did not receive DSS. ( C ) DAI was evaluated at day 8 by the scoring method of Cooper et al. ( D ) Representative H&E staining images of colon sections in each group. The lower right panel represents a colorectum of mice that did not receive DSS. Scale bar, 100 μm. ( E ) Histologic score of H&E staining image was evaluated by the scoring method of Williams et al. Data represent mean ± SEM. * p < 0.05, ** p < 0.01 by Dunnett’s multiple comparison test.
    Upa Selective Inhibitor Uk122, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/upa selective inhibitor uk122/product/Santa Cruz Biotechnology
    Average 93 stars, based on 3 article reviews
    upa selective inhibitor uk122 - by Bioz Stars, 2026-03
    93/100 stars

    Images

    1) Product Images from "Urokinase-type plasminogen activator blockade ameliorates experimental colitis in mice"

    Article Title: Urokinase-type plasminogen activator blockade ameliorates experimental colitis in mice

    Journal: Scientific Reports

    doi: 10.1038/s41598-023-29824-1

    Effect of uPA inhibitor on DSS-induced colitis in C57BL/6 J mice. ( A ) Male mice were administered 2% DSS in their drinking water for 1 week, and intraperitoneally injected with 2 mg/kg or 4 mg/kg UK122 or vehicle from day 1 to day 7 (n = 18 per group). They were sacrificed at day 8. ( B ) Representative macroscopic images of the colon in each group. The lower right panel represents a colorectum of mice that did not receive DSS. ( C ) DAI was evaluated at day 8 by the scoring method of Cooper et al. ( D ) Representative H&E staining images of colon sections in each group. The lower right panel represents a colorectum of mice that did not receive DSS. Scale bar, 100 μm. ( E ) Histologic score of H&E staining image was evaluated by the scoring method of Williams et al. Data represent mean ± SEM. * p < 0.05, ** p < 0.01 by Dunnett’s multiple comparison test.
    Figure Legend Snippet: Effect of uPA inhibitor on DSS-induced colitis in C57BL/6 J mice. ( A ) Male mice were administered 2% DSS in their drinking water for 1 week, and intraperitoneally injected with 2 mg/kg or 4 mg/kg UK122 or vehicle from day 1 to day 7 (n = 18 per group). They were sacrificed at day 8. ( B ) Representative macroscopic images of the colon in each group. The lower right panel represents a colorectum of mice that did not receive DSS. ( C ) DAI was evaluated at day 8 by the scoring method of Cooper et al. ( D ) Representative H&E staining images of colon sections in each group. The lower right panel represents a colorectum of mice that did not receive DSS. Scale bar, 100 μm. ( E ) Histologic score of H&E staining image was evaluated by the scoring method of Williams et al. Data represent mean ± SEM. * p < 0.05, ** p < 0.01 by Dunnett’s multiple comparison test.

    Techniques Used: Injection, Staining, Comparison

    Cytokine expression in colorectal tissue from DSS-treated uPA −/− mice, and C57BL/6 J mice intraperitoneally injected with UK122. ( A ) Cytokine concentration in the colorectal extracts of WT (n = 8) and uPA −/− (n = 10) mice measured using Bio-Plex Pro Mouse Cytokine 23-Plex Assay kit in triplicate. ( B ) Cytokine concentration in the colorectal extracts of 8 mice treated with 2 mg/kg or 4 mg/kg UK122 or vehicle measured using Bio-Plex Pro Mouse Cytokine 23-Plex Assay kit in duplicate. Data represent mean ± SEM. * p < 0.05, by Student’s t test ( A ) and Dunnett’s multiple comparison test ( B ).
    Figure Legend Snippet: Cytokine expression in colorectal tissue from DSS-treated uPA −/− mice, and C57BL/6 J mice intraperitoneally injected with UK122. ( A ) Cytokine concentration in the colorectal extracts of WT (n = 8) and uPA −/− (n = 10) mice measured using Bio-Plex Pro Mouse Cytokine 23-Plex Assay kit in triplicate. ( B ) Cytokine concentration in the colorectal extracts of 8 mice treated with 2 mg/kg or 4 mg/kg UK122 or vehicle measured using Bio-Plex Pro Mouse Cytokine 23-Plex Assay kit in duplicate. Data represent mean ± SEM. * p < 0.05, by Student’s t test ( A ) and Dunnett’s multiple comparison test ( B ).

    Techniques Used: Expressing, Injection, Concentration Assay, Plex Assay, Comparison



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    Effect of uPA inhibitor on DSS-induced colitis in C57BL/6 J mice. ( A ) Male mice were administered 2% DSS in their drinking water for 1 week, and intraperitoneally injected with 2 mg/kg or 4 mg/kg <t>UK122</t> or vehicle from day 1 to day 7 (n = 18 per group). They were sacrificed at day 8. ( B ) Representative macroscopic images of the colon in each group. The lower right panel represents a colorectum of mice that did not receive DSS. ( C ) DAI was evaluated at day 8 by the scoring method of Cooper et al. ( D ) Representative H&E staining images of colon sections in each group. The lower right panel represents a colorectum of mice that did not receive DSS. Scale bar, 100 μm. ( E ) Histologic score of H&E staining image was evaluated by the scoring method of Williams et al. Data represent mean ± SEM. * p < 0.05, ** p < 0.01 by Dunnett’s multiple comparison test.
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    Effect of uPA inhibitor on DSS-induced colitis in C57BL/6 J mice. ( A ) Male mice were administered 2% DSS in their drinking water for 1 week, and intraperitoneally injected with 2 mg/kg or 4 mg/kg <t>UK122</t> or vehicle from day 1 to day 7 (n = 18 per group). They were sacrificed at day 8. ( B ) Representative macroscopic images of the colon in each group. The lower right panel represents a colorectum of mice that did not receive DSS. ( C ) DAI was evaluated at day 8 by the scoring method of Cooper et al. ( D ) Representative H&E staining images of colon sections in each group. The lower right panel represents a colorectum of mice that did not receive DSS. Scale bar, 100 μm. ( E ) Histologic score of H&E staining image was evaluated by the scoring method of Williams et al. Data represent mean ± SEM. * p < 0.05, ** p < 0.01 by Dunnett’s multiple comparison test.
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    upa inhibitor ii  (Santa Cruz Biotechnology)
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    Effect of uPA inhibitor on DSS-induced colitis in C57BL/6 J mice. ( A ) Male mice were administered 2% DSS in their drinking water for 1 week, and intraperitoneally injected with 2 mg/kg or 4 mg/kg <t>UK122</t> or vehicle from day 1 to day 7 (n = 18 per group). They were sacrificed at day 8. ( B ) Representative macroscopic images of the colon in each group. The lower right panel represents a colorectum of mice that did not receive DSS. ( C ) DAI was evaluated at day 8 by the scoring method of Cooper et al. ( D ) Representative H&E staining images of colon sections in each group. The lower right panel represents a colorectum of mice that did not receive DSS. Scale bar, 100 μm. ( E ) Histologic score of H&E staining image was evaluated by the scoring method of Williams et al. Data represent mean ± SEM. * p < 0.05, ** p < 0.01 by Dunnett’s multiple comparison test.
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    upa inhibitor ii, uk122  (Merck KGaA)
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    Effect of uPA inhibitor on DSS-induced colitis in C57BL/6 J mice. ( A ) Male mice were administered 2% DSS in their drinking water for 1 week, and intraperitoneally injected with 2 mg/kg or 4 mg/kg <t>UK122</t> or vehicle from day 1 to day 7 (n = 18 per group). They were sacrificed at day 8. ( B ) Representative macroscopic images of the colon in each group. The lower right panel represents a colorectum of mice that did not receive DSS. ( C ) DAI was evaluated at day 8 by the scoring method of Cooper et al. ( D ) Representative H&E staining images of colon sections in each group. The lower right panel represents a colorectum of mice that did not receive DSS. Scale bar, 100 μm. ( E ) Histologic score of H&E staining image was evaluated by the scoring method of Williams et al. Data represent mean ± SEM. * p < 0.05, ** p < 0.01 by Dunnett’s multiple comparison test.
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    Image Search Results


    Effect of uPA inhibitor on DSS-induced colitis in C57BL/6 J mice. ( A ) Male mice were administered 2% DSS in their drinking water for 1 week, and intraperitoneally injected with 2 mg/kg or 4 mg/kg UK122 or vehicle from day 1 to day 7 (n = 18 per group). They were sacrificed at day 8. ( B ) Representative macroscopic images of the colon in each group. The lower right panel represents a colorectum of mice that did not receive DSS. ( C ) DAI was evaluated at day 8 by the scoring method of Cooper et al. ( D ) Representative H&E staining images of colon sections in each group. The lower right panel represents a colorectum of mice that did not receive DSS. Scale bar, 100 μm. ( E ) Histologic score of H&E staining image was evaluated by the scoring method of Williams et al. Data represent mean ± SEM. * p < 0.05, ** p < 0.01 by Dunnett’s multiple comparison test.

    Journal: Scientific Reports

    Article Title: Urokinase-type plasminogen activator blockade ameliorates experimental colitis in mice

    doi: 10.1038/s41598-023-29824-1

    Figure Lengend Snippet: Effect of uPA inhibitor on DSS-induced colitis in C57BL/6 J mice. ( A ) Male mice were administered 2% DSS in their drinking water for 1 week, and intraperitoneally injected with 2 mg/kg or 4 mg/kg UK122 or vehicle from day 1 to day 7 (n = 18 per group). They were sacrificed at day 8. ( B ) Representative macroscopic images of the colon in each group. The lower right panel represents a colorectum of mice that did not receive DSS. ( C ) DAI was evaluated at day 8 by the scoring method of Cooper et al. ( D ) Representative H&E staining images of colon sections in each group. The lower right panel represents a colorectum of mice that did not receive DSS. Scale bar, 100 μm. ( E ) Histologic score of H&E staining image was evaluated by the scoring method of Williams et al. Data represent mean ± SEM. * p < 0.05, ** p < 0.01 by Dunnett’s multiple comparison test.

    Article Snippet: The uPA-selective inhibitor UK122 (Santa Cruz Biotechnology, Dallas, TX) was dissolved in dimethyl sulfoxide (DMSO) and saline.

    Techniques: Injection, Staining, Comparison

    Cytokine expression in colorectal tissue from DSS-treated uPA −/− mice, and C57BL/6 J mice intraperitoneally injected with UK122. ( A ) Cytokine concentration in the colorectal extracts of WT (n = 8) and uPA −/− (n = 10) mice measured using Bio-Plex Pro Mouse Cytokine 23-Plex Assay kit in triplicate. ( B ) Cytokine concentration in the colorectal extracts of 8 mice treated with 2 mg/kg or 4 mg/kg UK122 or vehicle measured using Bio-Plex Pro Mouse Cytokine 23-Plex Assay kit in duplicate. Data represent mean ± SEM. * p < 0.05, by Student’s t test ( A ) and Dunnett’s multiple comparison test ( B ).

    Journal: Scientific Reports

    Article Title: Urokinase-type plasminogen activator blockade ameliorates experimental colitis in mice

    doi: 10.1038/s41598-023-29824-1

    Figure Lengend Snippet: Cytokine expression in colorectal tissue from DSS-treated uPA −/− mice, and C57BL/6 J mice intraperitoneally injected with UK122. ( A ) Cytokine concentration in the colorectal extracts of WT (n = 8) and uPA −/− (n = 10) mice measured using Bio-Plex Pro Mouse Cytokine 23-Plex Assay kit in triplicate. ( B ) Cytokine concentration in the colorectal extracts of 8 mice treated with 2 mg/kg or 4 mg/kg UK122 or vehicle measured using Bio-Plex Pro Mouse Cytokine 23-Plex Assay kit in duplicate. Data represent mean ± SEM. * p < 0.05, by Student’s t test ( A ) and Dunnett’s multiple comparison test ( B ).

    Article Snippet: The uPA-selective inhibitor UK122 (Santa Cruz Biotechnology, Dallas, TX) was dissolved in dimethyl sulfoxide (DMSO) and saline.

    Techniques: Expressing, Injection, Concentration Assay, Plex Assay, Comparison